HMG 150IU

HMG 150IU — Human Menopausal Gonadotropin by Dragon Pharma

HMG 150IU (Human Menopausal Gonadotropin, Menotropin) is Dragon Pharma's formulation of purified gonadotropins at 150IU per vial — comprising 75IU of Follicle-Stimulating Hormone (FSH) and 75IU of Luteinizing Hormone (LH) activity. Unlike synthetic or recombinant gonadotropins, HMG is derived from the urine of postmenopausal women — the origin of the "menopausal" in its name — whose high natural gonadotropin output provides a purified source of both FSH and LH simultaneously. In AAS recovery contexts, HMG provides the FSH component that HCG cannot, making it specifically valuable for spermatogenesis restoration.

Also searched as: HMG 150IU, Human Menopausal Gonadotropin, Menotropin, HMG fertility AAS recovery, Dragon Pharma HMG.

What HMG Is — The Postmenopausal Urine Origin

HMG's origin is unique among all compounds in the Dragon Pharma range and almost universally omitted from competitor content:

• Postmenopausal women produce very high levels of FSH and LH — because the ovaries are no longer functional, negative feedback from estrogen and progesterone is lost, driving the pituitary to produce large quantities of gonadotropins in a futile attempt to stimulate ovulation
• This gonadotropin-rich urine was identified in the 1950s as a practical source for fertility treatment — the first commercially available HMG (Pergonal, Serono Laboratories) was introduced in 1964 for ovulation induction
• Modern HMG is highly purified from this source — the gonadotropins are extracted, purified and standardised to contain 75IU FSH and 75IU LH activity per 75IU ampoule (or 150IU total as in this 150IU vial)
• This natural origin means HMG contains the exact same glycoprotein hormones as endogenous human FSH and LH — structurally identical to what the pituitary produces, not synthetic analogues

Why HMG Addresses What HCG Cannot — The FSH Requirement

This is the most critical information gap in competitor content and the primary clinical reason HMG exists as a distinct product from HCG:

• HCG (Human Chorionic Gonadotropin) is an LH analogue — it binds LH receptors on Leydig cells in the testes, stimulating testosterone production. It does not bind FSH receptors and has no FSH activity
• Spermatogenesis (sperm production) requires both LH and FSH signalling — LH drives Leydig cell testosterone production (which testosterone then acts locally in the testes to support sperm production), but FSH directly stimulates Sertoli cells which are the essential supporting cells for sperm maturation
• Without FSH, Sertoli cell function is impaired and spermatogenesis cannot fully recover — this is why HCG alone is insufficient for fertility restoration in men with HCG-responsive (but FSH-deficient) infertility
• HMG provides both the LH activity (75IU — same function as HCG at this dose) and the FSH activity (75IU) that Sertoli cells require — making it the complete gonadotropin replacement for spermatogenesis recovery

HMG vs HCG — The AAS Recovery Comparison

AAS Context — When HMG Is Specifically Indicated

HMG has specific clinical indications within AAS recovery that HCG does not cover:

• Fertility preservation during long AAS cycles: Extended AAS cycles (16+ weeks) with deep HPG suppression can significantly impair spermatogenesis. Adding HMG during the cycle (alongside or instead of HCG) maintains both Leydig and Sertoli cell function, preserving sperm production capacity throughout the suppressive period
• Post-cycle fertility restoration: For users planning conception after a cycle, spermatogenesis recovery with HCG alone may be incomplete due to FSH deficiency. HMG bridges this — providing FSH to Sertoli cells while the HPG axis recovers, accelerating return to full sperm production
• HCG-resistant cases: Some users have adequate testosterone recovery post-cycle with HCG or SERM-based PCT but persistent poor sperm parameters. Adding HMG provides the missing FSH signal to the Sertoli cells

Effects and Benefits

• Dual gonadotropin replacement — both FSH (75IU) and LH (75IU) activity from a single injection
• Sertoli cell stimulation via FSH — the only injectable product in the Dragon Pharma range providing this specific function
• Leydig cell testosterone stimulation via LH component — same effect as HCG at the LH receptor level
• Testicular volume maintenance and restoration — prevents or reverses testicular atrophy from prolonged HPG suppression
• Complete spermatogenesis restoration support — critical for AAS users prioritising fertility

Dosage and Administration

At 150IU per vial (75IU FSH + 75IU LH), each vial provides one full dose at the standard 150IU protocol or two doses at the conservative 75IU protocol. Reconstitute with bacteriostatic water. Inject subcutaneously. HMG is administered separately from HCG in most protocols — HMG 2-3× weekly for FSH support alongside or instead of HCG for LH support. HMG can also be combined with SERM-based PCT (Clomid, Nolvadex) for comprehensive HPG and fertility recovery.